Mitochondria are central hubs for cellular stress adaptation, with their function integrated with both apoptosis and autophagy pathways that determine cell fate. Alterations in mitochondrial ...
Concurrent Inhibition of The RAS Pathway and Autophagy As a Treatment Approach for Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that inhibition ...
PD-1 inhibitor combined with ablation in liver metastasis: A retrospective, multicenter study. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract does not include a ...
Autophagy is essentially the 'rubbish collection' of our cells. If there are problems in this process, which is so important for our health, diseases such as Parkinson's can result. In their latest ...
Autophagy—meaning “self-eating” in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...
A team of researchers from Academia Sinica and National Taiwan University has identified the Drosophila Cul2 substrate adaptor DmZer1 as a key regulator of protein quality control, acting at the ...
Autophagy is a natural, conserved process where cells degrade and recycle their own components, including damaged proteins and organelles. This targeted removal is orchestrated by cargo receptors, ...
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