Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

Neurotrophin signalling orchestrates a myriad of cellular events essential for the development, survival, and functional maintenance of sympathetic neurons. Neurotrophins such as nerve growth factor ...

Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons to ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear.

This is a preview. Log in through your library . Abstract βII-spectrin is the generally expressed member of the β-spectrin family of elongated polypeptides that form micrometer-scale networks ...

This is a preview. Log in through your library . Abstract KIF1A is a kinesin superfamily motor protein that transports synaptic vesicle precursors in axons. Cargo binding stimulates the dimerization ...

Researchers found that inhibiting GSK-3 led to less defects in the axonal transport process and less neuronal cell death, while inhibiting ERK1 led to more transport problems and more cell death. A ...

Scientists have long known that inherited neurodegenerative disorders, including Alzheimer's, Parkinson's or motor neuron ...

Indiana University researchers in the College of Arts and Sciences in Bloomington have identified a missing link that can help protect the brain from aging. Carnegie Mellon University's Jessica Zhang ...

Dysfunctional presenilin 1, infamous for misprocessing the amyloid precursor protein in familial Alzheimer’s disease, isn’t a one-trick pony. PS1 variants also weaken lysosomes, slow endosomal ...