Study confirms rare CYP2C19 and CYP2D6 variants reduce drug-metabolizing activity

A new in vivo pharmacokinetic recall study involving 114 participants in the Estonian Biobank has provided the first clinical ...
ascopubs.org

A drug interaction study between dextromethorphan and panobinostat (LBH589), an orally active deacetylase inhibitor, in patients with advanced cancer.

Ablating MUC1+ tumor and cancer stem cells by targeting the MUC1 oncoprotein with configurational-specific monoclonal antibodies and peptides. Background: Panobinostat (PAN; LBH589) has been found to ...
Medscape

Prediction of Cytochrome P450 Isoform Responsible for Metabolizing a Drug Molecule

Background: Different isoforms of Cytochrome P450 (CYP) metabolized different types of substrates (or drugs molecule) and make them soluble during biotransformation. Therefore, fate of any drug ...
Medscape

Prediction of Cytochrome P450 Isoform Responsible for Metabolizing a Drug Molecule

BMC Pharmacol. 2010;10(8):1-9. We have created an independent dataset in order to evaluate performance without any bias. For this, we downloaded from DrugBank 146 molecules that were reported to be ...