To many working biologists, DNA-modifying enzymes are tools, not unlike a pair of molecule-sized scissors. To Dr. Barry Stoddard, a professor in the Basic Sciences division at Fred Hutch, these ...

Enzymes that cut DNA at specific sites are called endonucleases; these enzymes play many roles in genomic replication, fidelity, and defense. The initial discovery of restriction endonucleases in the ...

A research team has discovered the key role that the APOBEC3A and APOBEC3B enzymes play in driving cancer mutations by modifying the DNA in tumor genomes, offering potential new targets for ...

There are many health problems that can be traced back to errors in the genetic code. There are also many potential benefits to genetic engineering outside of healthcare. Nature has already found ways ...

An important DNA modification is methylation, or the addition of a methyl group to the 5th carbon of cytosine. This forms 5-methylcytosine (5mC), typically associated with repression of gene ...

Today (September 19), the Lasker Foundation announced this year’s winners of the Lasker Awards. Zhijian “James” Chen, a biochemist at the University of Texas Southwestern Medical Center, was awarded ...

DNA phosphorothioate modification is a distinctive epigenetic alteration in which a non‐bridging oxygen atom within the DNA sugar-phosphate backbone is replaced by ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

A new family of enzymes enables precise cuts in single-stranded DNA, offering powerful new tools for genetic engineering and expanding possibilities in biotechnology. (Nanowerk News) A few years ago, ...

BOULDER, Colo.--(BUSINESS WIRE)--Watchmaker Genomics, a supplier of innovative products for molecular analysis, today announced a multi-year, co-exclusive agreement with Exact Sciences Corporation, a ...

Researchers from the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena, Germany, the Molecular Biotechnology Centre (MBC) in Turin and the University of Turin, Italy, have discovered ...