The ability of cells to polarize is essential for such processes as cell division, assembly of epithelia, neuronal outgrowth and cellular locomotion 1. To establish polarity, eukaryotic cells ...

Researchers have visualized at the molecular level how formins bind to the ends of actin filaments. This allowed them to uncover how formins mediate the addition of new actin molecules to a growing ...

Formins promote the assembly of actin filaments in the cytoplasm. This leads to the release of MAL (megakaryocytic acute leukaemia; also known as MRTF) from monomeric G-actin and the accumulation of ...

Actin is a highly abundant protein that controls the shape and movement of all our cells. Actin achieves this by assembling into filaments, one actin molecule at a time. There are as many as 15 ...

This is a preview. Log in through your library . Abstract Formins are large multidomain proteins required for assembly of actin cables that contribute to the polarity and division of animal and fungal ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 12 (Jun. 15, 1993), pp. 5554-5558 (5 pages) Mutations at the mouse limb deformity (ld) locus result in ...

Formins are made of two identical parts (red, orange) that encircle the actin (grey) filament in a ring-like conformation. “Our discovery allows us to interpret decades of biochemical studies on ...