Hirschsprung disease, also known as congenital megacolon, aganglionic megacolon or primary megacolon, is a functional bowel obstruction that usually manifests in newborn babies. It occurs due to the ...

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Defects in the protein Sox10, a transcription factor that regulates gene expression, may play a role in the development of post-operative GI dysfunction in Hirschsprung's disease patients, according ...

Hirschsprung-associated enterocolitis (HAEC): causes and possible treatments HAEC is associated with significant mortality and morbidity, yet its pathogenesis remains unknown. Changes in the colonic ...

A manometric technic is described for the diagnosis of Hirschsprung's disease without the necessity of deep-muscle rectal biopsy. Separate pressure recordings were obtained from the internal and ...

Q: Which doctor treats Hirschsprung disease? A: Hirschsprung disease is treated by a pediatric surgeon or pediatric gastroenterologist. Q: Is Hirschsprung disease hereditary? A: Hirschsprung disease ...

Researchers have developed a new mouse model of Hirschsprung's disease and associated enterocolitis and shed light on the disease progression. About one in every 5,000 babies is born without enteric ...

Dr. Marc Levitt is Surgical Director for the Center for Colorectal and Pelvic Reconstruction at Nationwide Children's Hospital. He contributed this article to Live Science's Expert Voices: Op-Ed & ...

Given the potential importance of common genetic variants in HSCR, and the failure to identify disease-causing rare mutations in most nonfamilial HSCR cases, our objective was to examine associations ...

When a newborn is unable to pass stool, the cause could be Hirschsprung’s Disease, a rare congenital disorder that can lead to serious complications. Dr. Michael Rollins explains the disease and how ...