Patients with serum ferritin levels higher than 1000 μg/L show a 91% increased risk for any fracture, with a doubled risk for vertebral and humerus fractures compared with those without iron overload.

To investigate the fertility of male patients with transfusion-dependent beta-thalassemia, and to use magnetic resonance imaging (MRI) as a novel method to assess the iron overload status of testis in ...

Background: Recently it has been found that iron is an important element in the natural history of hepatitis C. Serum markers of iron stores are frequently increased in chronic hepatitis C virus (HCV) ...

This perspective argues that Parkinson’s disease may involve functional iron deficiency, where bioavailable iron is limited despite normal or elevated total iron in the brain. The authors propose that ...

BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; HAMP, hepcidin; HFE, hereditary hemochromatosis protein; HJV, hemojuvelin; Holo-Tf, holo ...

Two infants with hypotonia and minor congenital anomalies were found to have a striking increase in the total body iron in the absence of any hemolysis or unusual iron intake. The increase in iron was ...

The protein that the liver uses to load iron has been identified by a researcher, thereby opening the door to potential strategies to treat “iron overload” disorders. One form of these genetic ...

Researchers at the University of Toronto and Toronto General Hospital have made a discovery that could prevent damage to the heart, pancreas and pituitary gland from excess iron with a simple pill.

For people who need blood transfusions, iron can accumulate in the heart and liver, causing damage and sometimes death. Doctors often prescribe medications called chelators that bind to iron and ...

Iron is essential for oxygen transport and energy metabolism, yet both deficiency and excess are linked to cardiovascular ...

Why is the TP53 gene important? The TP53 gene is often-mutated, and the most commonly mutated in human cancer. It is not only a tumor suppressor gene for most forms of cancer but is a key protein for ...