The metazoan Mediator is a multiprotein complex of about 30 subunits that seems to have key roles in the regulation of essentially all genes. Many of the individual subunits and the overall structural ...

In a major step toward achieving one of the key unsolved problems of structural biochemistry, the crystal structure of a large part of the yeast Mediator protein complex has been determined. Found in ...

Georg Winter's lab at CeMM uses chemical tools to understand the molecular basis of gene control and aberrations thereof in cancer. To do so, the team combines particularly fast-acting protein ...

Targeted cancer treatments - those that home in on the malignant cells and leave the healthy ones unscathed - have improved outcomes while reducing toxic side effects. But unfortunately, cancer cells ...