Having a pill that alleviates chronic pain without adverse side effects or the risk of addiction remains an unmet pharmaceutical need for millions of people currently using traditional opioid drugs.
Fentanyl, a mu-opioid receptor agonist, is one of the most commonly used analgesics in hospitals, and may induce long-lasting behavioral and somatosensory impairment in rodents. However, whether the ...
Distinct brain circuits drive two key components of addiction to the synthetic opioid drug fentanyl, according to a new finding published in Nature (2024, DOI: 10.1038/s41586-024-07440-x). The ...
Researchers at USF Health have discovered a new way opioid receptors can work that may lead to safer pain medications. Their findings show that certain experimental compounds can amplify pain relief ...
University of Florida scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional ...
Scientists are racing to redesign how powerful painkillers work, aiming to keep the relief that opioids provide while stripping away the worst dangers of addiction and overdose. Instead of tweaking ...
University of Florida scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional ...
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