The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

Researchers Tout Delivery Strategies that Have the Potential to Get New Drugs into Trials Sooner As more of the human genome is identified and characterized, new frontiers open for therapeutics. “The ...

RNA interference (RNAi) is making great strides as an indispensable strategy for target-specific knockdown of gene expression. Emerging second-generation technologies represent advances in RNAi design ...

(SALT LAKE CITY)—Dicer, an enzyme essential for life, cleaves long double-stranded RNA (dsRNA) into short pieces that regulate gene expression. But in many ways dsRNA molecules all look alike, and ...

In yeast cells, shown here, the Dicer protein protects DNA (bright blue) by helping to resolve conflicts between transcription and replication. If left unchecked, these conflicts can disrupt both ...