After three years of study, the researchers found that alpha-synuclein, a protein closely linked to Parkinson’s disease, forms an abnormal connection with an enzyme called ClpP. This enzyme normally ...
About 1 million Americans suffer from Parkinson's disease, with around 90,000 new cases diagnosed each year, according to the ...
Researchers visualize alpha-synuclein pathology in living patients with a neurodegenerative disorder
Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by the aggregation of alpha-synuclein in the brain. Now, scientists have developed a radioligand that facilitates the ...
Competition funded by Citadel founder and CEO Ken Griffin spurred a scientific race to develop an imaging tracer to visualize the key protein alpha-synuclein in the living brains of people with ...
Most cell surface proteins did not. But 16 did, including two found in the human dopamine neurons of the substantia nigra, a ...
Abnormal clumps of proteins like α-synuclein, amyloid beta and tau are associated with neurodegenerative conditions like ...
A research team led by Associate Professor Ayako Okado-Matsumoto from the Department of Biology at Toho University has made a significant finding that sheds new light on Dementia with Lewy Bodies (DLB ...
More than a decade has passed since researchers led by Dennis Selkoe of Brigham and Women’s Hospital in Boston first reported that when α-synuclein has its druthers, it prefers the company of three ...
Phosphorylation of α-synuclein at serine 129 has long been used as a marker of synucleinopathy—p-S129syn accumulates in Lewy bodies, after all. But does this modification have a physiological function ...
The so-called isolated REM-sleep behavior disorder is a condition that can provide an indication of Parkinson's disease well in advance. A research team headed by Professor Dr Erdem Gültekin Tamgüney ...
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