Morningstar

Saol Therapeutics Has Been Granted a Type A Meeting with the FDA to Determine the Path Forward for SL1009 in Pyruvate Dehydrogenase Complex Deficiency (PDCD)

FDA grants a Type A meeting on December 18th to review new and expanded datasets submitted by Saol to help identify a feasible path forward without the need for an additional clinical trial ROSWELL, ...
mccormick.northwestern.edu

The Geometric Code: Genome’s 3D Shape Functions as the Living Computer that Enabled Complex Life

Decades of research has viewed DNA as a sequence-based instruction manual; yet every cell in the body shares the same genes – so where is the language that writes the memory of cell identities?
Neurology Advisor

FDA Denies Approval of Dichloroacetate for Rare Mitochondrial Disorder

The Company is currently seeking a path forward with the FDA that would not require an additional clinical trial. The Food and Drug Administration (FDA) has issued a Complete Response Letter (CRL) to ...
WZZM

Families plead with FDA to approve rare disease treatment

GRAND RAPIDS, Mich. — For families of children with pyruvate dehydrogenase complex deficiency (PDCD), a rare metabolic disorder, hope is tied to one drug: DCA. The treatment is given orally and works ...
BioSpace

Saol Therapeutics Receives Complete Response Letter from FDA for SL1009 (DCA) for the Treatment of Pyruvate Dehydrogenase Complex Deficiency (PDCD)

ROSWELL, Ga. and DUBLIN and HAMILTON, Bermuda, Sept. 8, 2025 /PRNewswire/ -- Saol Therapeutics, a privately held, clinical-stage pharmaceutical company, today announced that the U.S. Food and Drug ...
Newsweek

Cam Films Mom Placing Baby in Crib—Soon After She’s Fighting for Her Life

A Michigan woman has shared dramatic footage of the moment her uterus began to rupture. Holly Cieslinski, from Grand Rapids, shared footage to TikTok @hollycski of the moment she lent over her ...
EurekAlert!

6-PPD quinone at environmentally relevant concentrations disrupts citric acid cycle in Caenorhabditis elegans: Role of reduction in acetyl CoA and pyruvate contents

6-PPDQ, has emerged as an environmental concern due to its widespread detection and toxic effects. In a study published in Environmental Chemistry and Ecotoxicology, researchers from Southeast ...
Scientific Research Publishing

Wu, P., Inskeep, K., Bowker-Kinley, M.M., Popov, K.M. and Harris, R.A. (1999) Mechanism Responsible for Inactivation of Skeletal Muscle Pyruvate Dehydrogenase Complex in ...

ABSTRACT: Skeletal muscle is the largest organ in the human body, and improving energy metabolism is crucial for maintaining and promoting health, including alleviating metabolic disorders like ...
Scientific Research Publishing

Huang, B., Wu, P., Bowker-Kinley, M.M. and Harris, R.A. (2002) Regulation of Pyruvate Dehydrogenase Kinase Expression by Peroxisome Proliferator-Activated Receptor-

ABSTRACT: Skeletal muscle is the largest organ in the human body, and improving energy metabolism is crucial for maintaining and promoting health, including alleviating metabolic disorders like ...
Carnegie Institution for Science

Nuclear pyruvate dehydrogenase complex regulates histone acetylation and transcriptional regulation in the ethylene response

Ethylene plays its essential roles in plant development, growth, and defense responses by controlling the transcriptional reprograming, in which EIN2-C-directed regulation of histone acetylation is ...
The EMBO Journal

Time-resolved mitochondrial screen identifies regulatory components of oxidative metabolism

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Defects in mitochondrial oxidative metabolism ...